Hiển thị các bài đăng có nhãn studies. Hiển thị tất cả bài đăng
Hiển thị các bài đăng có nhãn studies. Hiển thị tất cả bài đăng

Thứ Hai, 20 tháng 2, 2012

Bird Flu Studies Can Be Published After All: WHO

SATURDAY, Feb. 18 (HealthDay News) -- Research on a mutated, more contagious form of the bird flu virus can be published in full, the World Health Organization announced Friday, despite concerns that bioterrorists could use the information to start a pandemic.

The decision came during a special meeting of 22 bird flu experts in Geneva, Switzerland, that was convened by the WHO to discuss the "urgent issues" that have swirled around possible publication of the two bird flu studies since last November, The New York Times reported Saturday.

Most of those at the meeting felt that any theoretical terrorist risk was outweighed by the "real and present danger" of similar flu virus mutations occurring naturally in the wild, and by the need for the scientific community to share information that could help identify exactly when the virus might be developing the ability to spread more easily, Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases, told the Times. Fauci represented the United States at the meeting.

"The group consensus was that it was much more important to get this information to scientists in an easy way to allow them to work on the problem for the good of public health," Fauci said. "It was not unanimous, but a very strong consensus."

However, Fauci added, the United States was not part of that consensus. U.S. bio-security chiefs had urged last November that critical specifics of the papers remain unpublished.

Although the bird flu virus, known as H5N1, rarely infects people, it appears to be highly lethal when it does. Of about 600 known cases, more than half have been fatal. If the virus were able to spread more easily from birds to humans, experts have estimated that millions of people could die after being infected.

The two studies at the center of the debate were to be published in the journals Science and Nature late last year. The papers, which were funded by the U.S. National Institutes of Health, describe how the H5N1 virus could mutate relatively easily into a strain that could spread rapidly among humans. The research was done by scientists at the University of Wisconsin and in the Netherlands.

The editors of both journals said they plan to publish the papers in full at a future date.

"Discussions at the WHO meeting made it clear how ineffective redaction and restricted distribution would be for the Nature paper. It also underlined how beneficial publication of the full paper could be. So, that is how we intend to proceed," Dr. Philip Campbell, editor-in-chief of Nature, said in a statement. "As was expressed at the WHO meeting, there is a need first to explore how best to communicate the issues of publication to a concerned public, and to review safety assurance of labs who would act on this publication. I fully support the WHO's further efforts in this regard."

Speaking at a scientific meeting in Vancouver, Science editor-in-chief Bruce Alberts had this to say about the WHO decision: "So, my reading is that both Nature and Science are to wait until we get some further information from the WHO and other authorities of when, in fact, we are to publish the full manuscript."

Before the two studies can be published, the experts at the WHO meeting said, security assessments must be made, the Sydney Morning Herald reported.

Another meeting on the remaining issues will be held at a future date, the WHO said in a statement.

The scientists behind the research had agreed on Jan. 20 to honor a 60-day moratorium on further studies, the Herald reported, but that deadline will now be extended for an unspecified time to allow for a wider examination of the risks and for public discussion.

More information

For more on how the bird flu virus might be able to infect humans, visit the U.S. National Institute of Allergy and Infectious Diseases.


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Chủ Nhật, 19 tháng 2, 2012

Deadly bird flu studies to stay secret for now: WHO

GENEVA/LONDON (Reuters) - Two studies showing how scientists mutated the H5N1 bird flu virus into a form that could cause a deadly human pandemic will be published only after experts fully assess the risks, the World Health Organization (WHO) said on Friday.

Speaking after a high-level meeting of flu experts and U.S. security officials in Geneva, a WHO official said an deal had been reached in principle to keep details of the controversial work secret until deeper risk analyses could be carried out.

"There is a preference from a public health perspective for full disclosure of the information in these two studies. However there are significant public concerns surrounding this research that should first be addressed," said Keiji Fukuda, the WHO's assistant director-general for health security and environment.

The WHO called the meeting to break a deadlock between scientists who have studied the mutations needed to make H5N1 bird flu transmit between mammals, and the U.S. National Science Advisory Board for Biosecurity (NSABB), which wanted the work censored before it was published in scientific journals.

Biosecurity experts fear mutated forms of the virus that research teams in The Netherlands and the United States independently created could escape or fall into the wrong hands and be used to spark a pandemic worse than the 1918-19 outbreak of Spanish flu that killed up to 40 million people.

WHO spokesman Gregory Hartl said that because of these fears, "there must be a much fuller discussion of risk and benefits of research in this area and risks of virus itself."

But a scientist close to the NSABB who spoke to Reuters immediately after the decision said the board was deeply "frustrated" by the situation.

The only NSABB member attending the meeting was infectious disease expert Paul Keim of Northern Arizona University and he "got the hell beat out of him," the source said.

"It was a closed meeting dominated by flu people who have a vested interest in continuing this kind of work," he added.

The WHO said experts at the meeting included lead researchers of the two studies, scientific journals interested in publishing the research, funders of the research, countries who provided the viruses, bioethicists and directors from several WHO-linked laboratories specializing in influenza.

HIGH FATALITY RATE

The H5N1 virus, first detected in Hong Kong in 1997, is entrenched among poultry in many countries, mainly in Asia, but so far remains in a form that is hard for humans to catch.

It is known to have infected nearly 600 people worldwide since 2003, killing half of them, a far higher death rate than the H1N1 swine flu which caused a flu pandemic in 2009/2010.

Last year, two teams of scientists - one led by Ron Fouchier at Erasmus Medical Center and another led by Yoshihiro Kawaoka at the University of Wisconsin - said they had found that just a handful of mutations would allow H5N1 to spread like ordinary flu between mammals, and remain as deadly as it is now.

This type of research is seen as vital for scientists working to develop vaccines, diagnostic tests and anti-viral drugs that could be deployed in the event of an H5N1 pandemic.

In December, the NSABB asked two leading scientific journals, Nature and Science, to withhold details of the research for fear it could be used by bioterrorists.

They said a potentially deadlier form of bird flu poses one of the gravest known threats to the human population and justified the unprecedented call to censor the research.

The WHO voiced concerns, and flu researchers from around the world declared a 60-day moratorium on January 20 on "any research involving highly pathogenic avian influenza H5N1 viruses" that produce easily contagious forms.

Dr. Bruce Alberts, editor-in-chief of the journal Science, said it is now likely the paper submitted to Science and to the journal Nature will be published in full.

Alberts said it is still not clear how the scientists in Geneva plan to handle biosafety issues mentioned by the group, and it is still not clear when the papers will be published, but it will likely not be years.

"I hope this does not cause the world governments and WHO to stop working on this problem," Alberts said of any potential fallout from the decision at a news briefing at the American Association for the Advancement of Science meeting in Vancouver.

When asked how the journal is safeguarding copies of the as-yet-unpublished paper, he said it is in a locked electronic file and is password protected. And the magazine has asked reviewers of the paper to destroy their review copies.

Fouchier, who took part in the two-day meeting at the WHO which ended on Friday, said the consensus of experts and officials there was "that in the interest of public health, the full paper should be published" at some future date.

"This was based on the high public health impact of this work and the need to share the details of the studies with a very big community in the interest of science, surveillance and public health on the whole," he told reporters.

In its current form, people can contract H5N1 only through close contact with ducks, chickens or other birds that carry it, and not from infected individuals.

But H5N1 can acquire mutations that allow it to live in the upper respiratory tract rather than the lower, and the Dutch and U.S. researchers found a way to make it travel via airborne droplets between infected ferrets. Flu viruses are thought to behave similarly in the animals and in people.

Asked about the potential bioterrorism risks of his and the U.S. team's work, Fouchier said "it was the view of the entire group" at the meeting that the risks that this particular virus or flu viruses in general could be used as bioterrorism agents "would be very, very slim".

"The risks are not nil, but they are very, very small."

(Additional reporting by Sharon Begley in New York and Julie Steenhuysen in Chicago; editing by Andrew Roche and Todd Eastham)


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Deadly bird flu studies to stay secret for now: WHO

GENEVA/LONDON (Reuters) - Two studies showing how scientists mutated the H5N1 bird flu virus into a form that could cause a deadly human pandemic will be published only after experts fully assess the risks, the World Health Organization (WHO) said on Friday.

Speaking after a high-level meeting of flu experts and U.S. security officials in Geneva, a WHO official said an deal had been reached in principle to keep details of the controversial work secret until deeper risk analyses could be carried out.

"There is a preference from a public health perspective for full disclosure of the information in these two studies. However there are significant public concerns surrounding this research that should first be addressed," said Keiji Fukuda, the WHO's assistant director-general for health security and environment.

The WHO called the meeting to break a deadlock between scientists who have studied the mutations needed to make H5N1 bird flu transmit between mammals, and the U.S. National Science Advisory Board for Biosecurity (NSABB), which wanted the work censored before it was published in scientific journals.

Biosecurity experts fear mutated forms of the virus that research teams in The Netherlands and the United States independently created could escape or fall into the wrong hands and be used to spark a pandemic worse than the 1918-19 outbreak of Spanish flu that killed up to 40 million people.

WHO spokesman Gregory Hartl said that because of these fears, "there must be a much fuller discussion of risk and benefits of research in this area and risks of virus itself."

But a scientist close to the NSABB who spoke to Reuters immediately after the decision said the board was deeply "frustrated" by the situation.

The only NSABB member attending the meeting was infectious disease expert Paul Keim of Northern Arizona University and he "got the hell beat out of him," the source said.

"It was a closed meeting dominated by flu people who have a vested interest in continuing this kind of work," he added.

The WHO said experts at the meeting included lead researchers of the two studies, scientific journals interested in publishing the research, funders of the research, countries who provided the viruses, bioethicists and directors from several WHO-linked laboratories specializing in influenza.

HIGH FATALITY RATE

The H5N1 virus, first detected in Hong Kong in 1997, is entrenched among poultry in many countries, mainly in Asia, but so far remains in a form that is hard for humans to catch.

It is known to have infected nearly 600 people worldwide since 2003, killing half of them, a far higher death rate than the H1N1 swine flu which caused a flu pandemic in 2009/2010.

Last year, two teams of scientists - one led by Ron Fouchier at Erasmus Medical Center and another led by Yoshihiro Kawaoka at the University of Wisconsin - said they had found that just a handful of mutations would allow H5N1 to spread like ordinary flu between mammals, and remain as deadly as it is now.

This type of research is seen as vital for scientists working to develop vaccines, diagnostic tests and anti-viral drugs that could be deployed in the event of an H5N1 pandemic.

In December, the NSABB asked two leading scientific journals, Nature and Science, to withhold details of the research for fear it could be used by bioterrorists.

They said a potentially deadlier form of bird flu poses one of the gravest known threats to the human population and justified the unprecedented call to censor the research.

The WHO voiced concerns, and flu researchers from around the world declared a 60-day moratorium on January 20 on "any research involving highly pathogenic avian influenza H5N1 viruses" that produce easily contagious forms.

Dr. Bruce Alberts, editor-in-chief of the journal Science, said it is now likely the paper submitted to Science and to the journal Nature will be published in full.

Alberts said it is still not clear how the scientists in Geneva plan to handle biosafety issues mentioned by the group, and it is still not clear when the papers will be published, but it will likely not be years.

"I hope this does not cause the world governments and WHO to stop working on this problem," Alberts said of any potential fallout from the decision at a news briefing at the American Association for the Advancement of Science meeting in Vancouver.

When asked how the journal is safeguarding copies of the as-yet-unpublished paper, he said it is in a locked electronic file and is password protected. And the magazine has asked reviewers of the paper to destroy their review copies.

Fouchier, who took part in the two-day meeting at the WHO which ended on Friday, said the consensus of experts and officials there was "that in the interest of public health, the full paper should be published" at some future date.

"This was based on the high public health impact of this work and the need to share the details of the studies with a very big community in the interest of science, surveillance and public health on the whole," he told reporters.

In its current form, people can contract H5N1 only through close contact with ducks, chickens or other birds that carry it, and not from infected individuals.

But H5N1 can acquire mutations that allow it to live in the upper respiratory tract rather than the lower, and the Dutch and U.S. researchers found a way to make it travel via airborne droplets between infected ferrets. Flu viruses are thought to behave similarly in the animals and in people.

Asked about the potential bioterrorism risks of his and the U.S. team's work, Fouchier said "it was the view of the entire group" at the meeting that the risks that this particular virus or flu viruses in general could be used as bioterrorism agents "would be very, very slim".

"The risks are not nil, but they are very, very small."

(Additional reporting by Sharon Begley in New York and Julie Steenhuysen in Chicago; editing by Andrew Roche and Todd Eastham)


View the original article here